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Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 266-276 doi: 10.1007/s11684-017-0530-y
Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet–induced postnatal childhood obesity and puberty.
Keywords: postnatal HFD feeding obesity kisspeptin HPG axis precocious puberty
Five-axis rough machining for impellers
Ruolong QI, Weijun LIU, Hongyou BIAN, Lun LI
Frontiers of Mechanical Engineering 2009, Volume 4, Issue 1, Pages 71-76 doi: 10.1007/s11465-009-0010-4
Keywords: five-axis impeller tool-path planning flank milling ruled surface
Kinematic error separation on five-axis NC machine tool based on telescoping double ball bar
Min WANG, Jianzhong HU, Tao ZAN
Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4, Pages 431-437 doi: 10.1007/s11465-010-0110-1
Keywords: error modeling error separation telescoping double ball bar five-axis numerical control (NC) machining
Optimization model for rotor blades of horizontal axis wind turbines
LIU Xiong, CHEN Yan, YE Zhiquan
Frontiers of Mechanical Engineering 2007, Volume 2, Issue 4, Pages 483-488 doi: 10.1007/s11465-007-0084-9
Keywords: population extended algorithm developed optimization accurate
Application of Porous Aerostatic Bearings in Three-axis Table
Du Jinming
Strategic Study of CAE 2005, Volume 7, Issue 1, Pages 65-68
Keywords: aerostatic bearings porous orifice restricted three-axis table
Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower
Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG
Frontiers in Energy 2022, Volume 16, Issue 4, Pages 683-696 doi: 10.1007/s11708-020-0689-9
Keywords: vertical axis water turbine eye-shaped vertical water baffle pico hydropower
Aqeel AHMED, Muhammad WASIF, Anis FATIMA, Liming WANG, Syed Amir IQBAL
Frontiers of Mechanical Engineering 2021, Volume 16, Issue 2, Pages 298-314 doi: 10.1007/s11465-020-0621-3
Keywords: workpiece setup parameter five-axis space utilization setup parameters machine tool
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
Fung Zhao, Eric W.-F. Lam
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 376-380 doi: 10.1007/s11684-012-0228-0
Keywords: FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis
Estimation of power in low velocity vertical axis wind turbine
Sampath S. S.,Sawan SHETTY,Chithirai Pon Selvan M.
Frontiers of Mechanical Engineering 2015, Volume 10, Issue 2, Pages 211-218 doi: 10.1007/s11465-015-0338-x
The present work involves in the construction of a vertical axis wind turbine and the determination
Keywords: wind turbine shaft design power generation generator
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 295-305 doi: 10.1007/s11684-021-0857-2
Keywords: chronic heart failure trimethylamine-N-oxide flavin monooxygenase 3 single nucleotide polymorphism
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 442-458 doi: 10.1007/s11684-021-0877-y
Keywords: T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination
CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 287-293 doi: 10.1007/s11684-007-0055-x
Keywords: control function production surgical Complex
Xia Dunzhu,Zhou Bailing,Wang Shourong
Strategic Study of CAE 2007, Volume 9, Issue 8, Pages 66-68
Keywords: silicon micromechanical z-axis gyroscope negative electrostatic spring constant feedback force generator
Atypical pituitary hormone–target tissue axis
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 1-17 doi: 10.1007/s11684-022-0973-7
Keywords: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Analysis and characterization of wind-solar-constant torque spring hybridized model
Shantanu ACHARYA,Subhadeep BHATTACHARJEE
Frontiers in Energy 2014, Volume 8, Issue 3, Pages 279-289 doi: 10.1007/s11708-014-0312-z
Keywords: hybrid vertical axis wind turbine Stirling engine solar-thermal energy wind energy constant torque spring
Title Author Date Type Operation
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty
Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu
Journal Article
Five-axis rough machining for impellers
Ruolong QI, Weijun LIU, Hongyou BIAN, Lun LI
Journal Article
Kinematic error separation on five-axis NC machine tool based on telescoping double ball bar
Min WANG, Jianzhong HU, Tao ZAN
Journal Article
Optimization model for rotor blades of horizontal axis wind turbines
LIU Xiong, CHEN Yan, YE Zhiquan
Journal Article
Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower
Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG
Journal Article
Determination of the feasible setup parameters of a workpiece to maximize the utilization of a five-axis
Aqeel AHMED, Muhammad WASIF, Anis FATIMA, Liming WANG, Syed Amir IQBAL
Journal Article
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
Fung Zhao, Eric W.-F. Lam
Journal Article
Estimation of power in low velocity vertical axis wind turbine
Sampath S. S.,Sawan SHETTY,Chithirai Pon Selvan M.
Journal Article
FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection
Journal Article
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
Journal Article
Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular
CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming
Journal Article
Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical Vibrating zaxis
Xia Dunzhu,Zhou Bailing,Wang Shourong
Journal Article